ANNOTATE
Annotates are additional comments for an entry. Each annotate belongs to a comment category and contains free text. A reference link is given in square brackets after the comment, if available.
category   A tag to categorize the type of comment.
List of categories used:
  • by analogy to: <XNnnnnnnnnn>
    • For reactions deduced by analogy to other reactions.
    • + quality "putative"
  • CONFLICT! (text mentions both ACCNOS)
    • If a conflict exists between two papers, this is used to indicate that one exists, and in addition to the annotates of those papers, a third annotate with category "CONFLICT!" is entered, which in its text body mentions the accession numbers of those papers.
  • disease
    • Tells about in which disease(s) the molecule is involved. Queries can be executed by using keywords out of a list  Disease.
  • enzyme classification
    • Mentions the EC No.
  • experimental inhibitor
    • Names artificial compounds that can inhibit reactions or the function of molecules.
  • general
    • Contains comments that do not fit elsewhere.
  • GO: biological process
    • Associated GO-terms (Gene Ontology) and GO evidence code:
      e.g. "induction of proapoptotic gene products; IEA"
      hyperlink containing the corresponding GO ID (here GO:0008633)
    • Associations of TRANSPATH® Molecules with Gene Ontology terms (Gene Ontology: tool for the unification of biology. The Gene Ontology Consortium (2000) Nature Genet. 25: 25-29) were mainly obtained by electronic annotation using a gene association data list from Compugen Inc. (http://www.cgen.com/, http://www.labonweb.com).
  • historical
  • kinetics
    • Specification of kinetic parameters, e.g. KM = 2.4 mmol/l.
  • mechanism
    • Gives information about the mechanism of a reaction, e.g. signaling by substructures (motifs, part of complexes) or phosphorylation sites, e.g. xxx is phosphorylated at Tyr32.
  • methods
    • Contains additional information about methods and material used in experiments that are listed in the fields location positive/negative and experiment(s).
  • physiological function
    • Mentions physiological or environmental influences that affect the certain molecule or reaction, or tells something about the effects the entry has; e.g. IL-1 has inflammatory effects.
  • sequence
  • structure

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