AC

Accession Number

accession number of the mutated factor

ID

Identifier

{species acronym (e.g. HS for Homo sapiens)}${"m"(for mutated)}{TRANSFAC® factor name (e.g. p53)}

DT

Date

creation date; author

DT

Date

date of last update; updater

MF->MN

Mutated Factor Name

{"m" (for mutated) } {TRANSFAC® factor name} ({mutation name}); example: mER (S810L)

FA

Wildtype Factor

link to wildtype factor in TRANSFAC® (via accession number)

OS

Species

biological species (TRANSFAC®)

OC

Taxonomic Classification

systematic biological classification of the species (TRANSFAC®)

CL

Factor Class

assignment of the factor to the comprehensive transcription factor classification (class accession number; class identifier; decimal classification number)

SZ

Size

number of amino acids of the mutated factor; calculated molecular mass in kDa

SQ

Protein Sequence

amino acid sequence of the mutated factor

SC

Sequence Source

source of the protein sequence (e.g. EMBL accession number)

FT

Feature Table

local features of the mutated factor: remaining wildtype factor features as well as new features; first position - last position - feature

CP

Cell Positive

organs/cells in which the mutated factor has been demonstrated to be expressed

CN

Cell Negative

organs/cells in which the mutated factor has been demonstrated NOT to be expressed

GF

Global Features

structural information (e.g. the mutation alters the position of helix 3), homologies (the mutated amino acid lies in a conserved region), etc.

FF

Functional Features

funtional properties of the mutated factor such as altered DNA- or ligand-binding, protein interaction, and transactivation

BS

Binding Site(s)

link to a TRANSFAC® Site, shown to be bound by the mutated transcription factor

GT

Genotype

link to the Genotype table (via accession number); phenotype name

DR

External Databases

name of database (EMBL/Genbank/DDBJ, SWISS-PROT), link via database accession number; in case of EMBL/Genbank/DDBJ cross-links: (r) denotes reference to a RNA/cDNA, (g) to a genomic DNA sequence

RN

Reference Number

RX

Reference MEDLINE ID

RA

Reference Author(s)

RT

Reference Title

RL

Reference Journal